1,888 research outputs found
The Shearing HI Spiral Pattern of NGC 1365
The Tremaine-Weinberg equations are solved for a pattern speed that is
allowed to vary with radius. The solution method transforms an integral
equation for the pattern speed to a least squares problem with well established
procedures for statistical analysis. The method applied to the HI spiral
pattern of the barred, grand-design galaxy NGC 1365 produced convincing
evidence for a radial dependence in the pattern speed. The pattern speed
behaves approximately as 1/r, and is very similar to the material speed. There
are no clear indications of corotation or Lindblad resonances. Tests show that
the results are not selection biased, and that the method is not measuring the
material speed. Other methods of solving the Tremaine-Weinberg equations for
shearing patterns were found to produce results in agreement with those
obtained using the current method. Previous estimates that relied on the
assumptions of the density-wave interpretation of spiral structure are
inconsistent with the results obtained using the current method. The results
are consistent with spiral structure theories that allow for shearing patterns,
and contradict fundamental assumptions in the density-wave interpretation that
are often used for finding spiral arm pattern speeds. The spiral pattern is
winding on a characteristic timescale of ~ 500 Myrs.Comment: Accepted for publication in The Astrophysical Journa
Jet-Medium Interactions with Identified Particles
Identified particles have long been of great interest at RHIC in large part
because of the baryon/meson differences observed at intermediate and the
implications for hadronization via quark coalescence. With recent high
statistics data identified particles are also now central to understanding the
details of the jet-medium interactions and energy loss and hadron formation at
intermediate and high . In particular, high identified particle
spectra along with two-particle correlations triggered with direct photons,
neutral pions or electrons from heavy flavor decay with hadrons can provide
information about how medium modifications to jet fragmentation depend on
parton type. I will review recent results with identified particles both in
heavy ion systems and the reference measurements in p+p collisions.Comment: Proceedings for Quark Matter 2009, Knoxville T
Using small-angle X-ray scattering to investigate the compaction behaviour of a granulated clay
The compaction behaviour of a commercial granulated clay (magnesium aluminium smectite, gMgSm) was investigated using macroscopic pressure-density measurements, X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray microtomography (XμT) and small-angle X-ray scattering (SAXS). This material was studied as a potential compaction excipient for pharmaceutical tabletting, but also as a model system demonstrating the capabilities of SAXS for investigating compaction in other situations.
Bulk compaction measurements showed that the gMgSm was more difficult to compact than polymeric pharmaceutical excipients such as spheronised microcrystalline cellulose (sMCC), corresponding to harder granules. Moreover, in spite of using lubrication (magnesium stearate) on the tooling surfaces, rather high ejection forces were observed, which may cause problems during commercial tabletting, requiring further amelioration. Although the compacted gMgSm specimens were more porous, however, they still exhibited acceptable cohesive strengths, comparable to sMCC. Hence, there may be scope for using granular clay as one component of a tabletting formulation.
Following principles established in previous work, SAXS revealed information concerning the intragranular structure of the gMgSm and its response to compaction. The results showed that little compression of the intragranular morphology occurred below a relative density of 0 · 6, suggesting that granule rearrangements or fragmentation were the dominant mechanisms during this stage. By contrast, granule deformation became considerably more important at higher relative density, which also coincided with a significant increase in the cohesive strength of compacted specimens.
Spatially-resolved SAXS data was also used to investigate local variations in compaction behaviour within specimens of different shape. The results revealed the expected patterns of density variations within flat-faced cylindrical specimens. Significant variations in density, the magnitude of compressive strain and principal strain direction were also revealed in the vicinity of a debossed feature (a diametral notch) and within bi-convex specimens. The variations in compaction around the debossed notch, with a small region of high density below and low density along the flanks, appeared to be responsible for extensive cracking, which could also cause problems in commercial tabletting
Incidence of fracture in adjacent levels in patients treated with balloon kyphoplasty: a review of the literature
The available evidence suggests that the treatment of painful vertebral compression fractures (VCFs) secondary to osteoporosis or multiple myeloma, by cement augmentation with balloon kyphoplasty (BK), is both safe and effective. However, there is uncertainty in the literature concerning the potential of the procedure to influence the risk for adjacent segment fracture. The aim of this article is to review the available peer-reviewed literature, regarding adjacent vertebral body fractures after kyphoplasty augmentation
AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats
© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients with malignant gliomas can be impaired. Many clinical studies have demonstrated that part of patients, adults or children, diagnosed with glioblastoma will suffer from cognitive deficiency during their clinical course, especially in long-term survivors. Many nanoparticles (NPs) can inhibit the biological functions of tumours by modulating tumour-associated inflammation, which provokes angiogenesis and tumour growth. As one of the best antiviral nanoparticles (AVNPs), AVNP2 is the 2nd generation of AVNP2 that have been conjugated to graphite-graphene for improving physiochemical performance and reducing toxicity. AVNP2 inactivates viruses, such as the H1N1 and H5N1influenza viruses and even the SARS coronavirus, while it inhibits bacteria, such as MRSA and E. coli. As antimicrobials, nanoparticles are considered to be one of the vectors for the administration of therapeutic compounds. Yet, little is known about their potential functionalities and toxicities to the neurotoxic effects of cancer. Herein, we explored the functionality of AVNP2 on inhibiting C6 in glioma-bearing rats. The novel object-recognition test and open-field test showed that AVNP2 significantly improved the neuro-behaviour affected by C6 glioma. AVNP2 also alleviated the decline of long-term potentiation (LTP) and the decreased density of dendritic spines in the CA1 region induced by C6. Western blot assay and immunofluorescence staining showed that the expressions of synaptic-related proteins (PSD-95 and SYP) were increased, and these findings were in accordance with the results mentioned above. It revealed that the sizes of tumours in C6 glioma-bearing rats were smaller after treatment with AVNP2. The decreased expression of inflammatory factors (IL-1β, IL-6 and TNF-α) by Western blotting assay and ELISA, angiogenesis protein (VEGF) by Western blotting assay and other related proteins (BDNF, NF-ĸB, iNOS and COX-2) by Western blotting assay in peri-tumour tissue indicated that AVNP2 could control tumour-associated inflammation, thus efficiently ameliorating the local inflammatory condition and, to some extent, inhibiting angiogenesis in C6-bearing rats. In conclusion, our results suggested that AVNP2 could have an effect on the peri-tumor environment, obviously restraining the growth progress of gliomas, and eventually improving cognitive levels in C6-bearing rats.Peer reviewedProo
Endoscopic treatment of vesicoureteral reflux in pediatric patients
Endoscopic treatment is a minimally invasive treatment for managing patients with vesicoureteral reflux (VUR). Although several bulking agents have been used for endoscopic treatment, dextranomer/hyaluronic acid is the only bulking agent currently approved by the U.S. Food and Drug Administration for treating VUR. Endoscopic treatment of VUR has gained great popularity owing to several obvious benefits, including short operative time, short hospital stay, minimal invasiveness, high efficacy, low complication rate, and reduced cost. Initially, the success rates of endoscopic treatment have been lower than that of open antireflux surgery. However, because injection techniques have been developed, a recent study showed higher success rates of endoscopic treatment than open surgery in the treatment of patients with intermediate- and high-grade VUR. Despite the controversy surrounding its effectiveness, endoscopic treatment is considered a valuable treatment option and viable alternative to long-term antibiotic prophylaxis
A multispeaker dataset of raw and reconstructed speech production real-time MRI video and 3D volumetric images
Real-time magnetic resonance imaging (RT-MRI) of human speech production is
enabling significant advances in speech science, linguistics, bio-inspired
speech technology development, and clinical applications. Easy access to RT-MRI
is however limited, and comprehensive datasets with broad access are needed to
catalyze research across numerous domains. The imaging of the rapidly moving
articulators and dynamic airway shaping during speech demands high
spatio-temporal resolution and robust reconstruction methods. Further, while
reconstructed images have been published, to-date there is no open dataset
providing raw multi-coil RT-MRI data from an optimized speech production
experimental setup. Such datasets could enable new and improved methods for
dynamic image reconstruction, artifact correction, feature extraction, and
direct extraction of linguistically-relevant biomarkers. The present dataset
offers a unique corpus of 2D sagittal-view RT-MRI videos along with
synchronized audio for 75 subjects performing linguistically motivated speech
tasks, alongside the corresponding first-ever public domain raw RT-MRI data.
The dataset also includes 3D volumetric vocal tract MRI during sustained speech
sounds and high-resolution static anatomical T2-weighted upper airway MRI for
each subject.Comment: 27 pages, 6 figures, 5 tables, submitted to Nature Scientific Dat
The influence of age, delay of repair, and tendon involvement in acute rotator cuff tears: Structural and clinical outcomes after repair of 42 shoulders
Background and purpose Few authors have considered the outcome after acute traumatic rotator cuff tears in previously asymptomatic patients. We investigated whether delay of surgery, age at repair, and the number of cuff tendons involved affect the structural and clinical outcome. Patients and methods 42 patients with pseudoparalysis after trauma and no previous history of shoulder symptoms were included. A full-thickness tear in at least 1 of the rotator cuff tendons was diagnosed in all patients. Mean time to surgery was 38 (6-91) days. Follow-up at a mean of 39 (12-108) months after surgery included ultrasound, plain radiographs, Constant-Murley score, DASH score, and western Ontario rotator cuff (WORC) score. Results At follow-up, 4 patients had a full-thickness tear and 9 had a partial-thickness tear in the repaired shoulder. No correlation between the structural or clinical outcome and the time to repair within 3 months was found. The patients with a tendon defect at follow-up had a statistically significantly lower Constant-Murley score and WORC index in the injured shoulder and were significantly older than those with intact tendons. The outcomes were similar irrespective of the number of tendons repaired. Interpretation A delay of 3 months to repair had no effect on outcome. The patients with cuff defects at follow-up were older and they had a worse clinical outcome. Multi-tendon injury did not generate worse outcomes than single-tendon tears at follow-up
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